https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2967 Wed 24 Jul 2013 22:50:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42676 Wed 22 Mar 2023 14:34:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48900 Wed 19 Apr 2023 16:40:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25928 −9) more prevalent in genomic regions that are likely to have undergone recent positive selection in humans (i.e., with a low NSS score). Variants in brain-related genes with a low NSS score confer significantly higher susceptibility than variants in other brain-related genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes. The false discovery rate conditional on the evolutionary proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with schizophrenia and other psychiatric disorders or linked to brain development. Conclusions: Our results suggest that there is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human.]]> Wed 12 Aug 2020 09:42:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11770 Wed 11 Apr 2018 17:17:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26719 -8). There were 693 and 219 independent loci with model-based replication rates ≥80% and ≥90%, respectively. Compared to analyses not incorporating relative enrichment scores, CM3 increased out-of-sample yield for SNPs that replicate at a given rate. This demonstrates that replication probabilities can be more accurately estimated using prior enrichment information with CM3.]]> Wed 11 Apr 2018 17:05:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23292 Wed 11 Apr 2018 15:09:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18037 Wed 11 Apr 2018 14:27:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29038 Wed 11 Apr 2018 14:13:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1111 Wed 11 Apr 2018 13:29:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15192 Wed 11 Apr 2018 11:39:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4362 Wed 11 Apr 2018 11:36:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7526 Wed 11 Apr 2018 10:11:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29042 Wed 11 Apr 2018 09:36:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15118 Wed 11 Apr 2018 09:18:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54632 Wed 06 Mar 2024 10:59:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48767 Wed 05 Apr 2023 13:55:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33390 Wed 04 Sep 2019 10:12:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44746 Tue 21 Mar 2023 16:53:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45935 Tue 08 Nov 2022 10:00:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46890 Tue 06 Dec 2022 12:02:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33669 Iba1, Gfap, IL1-β and TNF-α mRNA levels in the cingulate cortex (CC) in adult offspring exposed to maternal immune activation. Prenatal exposure to immune activation had a significant main effect on microglial IBA1-positive immunoreactive material (IBA1+IRM) in the corpus callosum; post-hoc analyses identified a significant increase in GD19 offspring, but not GD10. No change in was observed in the CC. In contrast, maternal immune activation had a significant main effect on GFAP+IRM in the CC at GD19 (not GD10); post-hoc analyses only identified a strong trend towards increased GFAP+IRM in the GD19 offspring, with no white matter changes. This suggests late gestation maternal immune activation causes subtle alterations to microglia and astrocytes in the adult offspring.]]> Tue 04 Jun 2019 13:36:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34283 −15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10⁻⁶). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10⁻¹¹) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10⁻⁵). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.]]> Tue 03 Sep 2019 18:30:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33388 Tue 03 Sep 2019 17:54:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33389 Tue 03 Sep 2019 17:54:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46136 Thu 29 Jun 2023 12:51:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:534 Thu 25 Jul 2013 09:10:32 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47202 Thu 15 Dec 2022 11:18:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54816 Thu 14 Mar 2024 14:38:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54811 Thu 14 Mar 2024 14:24:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34615 Thu 04 Apr 2019 09:04:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7882 Sat 24 Mar 2018 08:41:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7124 Sat 24 Mar 2018 08:34:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1288 Sat 24 Mar 2018 08:32:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1083 Sat 24 Mar 2018 08:32:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1231 Sat 24 Mar 2018 08:28:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2883 Sat 24 Mar 2018 08:27:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20953 Sat 24 Mar 2018 08:06:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21387 Catechol-O-methyltransferase (COMT) Val¹⁵⁸Met polymorphism, a common genetic variant known to affect cognition and prefrontal dopamine levels. Participants were 429 schizophrenia/schizoaffective cases from the Australian Schizophrenia Research Bank (ASRB). Cognitive performance was assessed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), Controlled Oral Word Association Test (COWAT), Letter Number Sequencing (LNS) test, and the Wechsler Test of Adult Reading (WTAR). Hierarchical regression was used to test the main effects and additive interaction effects of genotype and childhood trauma in the domains of physical abuse, emotional abuse, and emotional neglect, on cognition and symptom profiles of clinical cases. Consistent with previous findings, COMT Val homozygotes performed worse on cognitive measures in the absence of childhood adversity. In addition, a significant interaction between COMT genotype and physical abuse was associated with better executive function in Val homozygotes, relative to those of the same genotype with no history of abuse. Finally, the severity of positive symptoms was greater in Met carriers who had experienced physical abuse, and the severity of negative symptoms in Met carriers was greater in the presence of emotional neglect. These results suggest that the possible epigenetic modulation of the expression of the COMT Val¹⁵⁸Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers.]]> Sat 24 Mar 2018 08:05:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17373 Sat 24 Mar 2018 08:01:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20972 Sat 24 Mar 2018 07:54:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20136 Sat 24 Mar 2018 07:51:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20133 Sat 24 Mar 2018 07:51:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20137 Sat 24 Mar 2018 07:51:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20134 Sat 24 Mar 2018 07:51:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20135 Sat 24 Mar 2018 07:51:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5407 Sat 24 Mar 2018 07:48:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26307 Sat 24 Mar 2018 07:40:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26149 +) and somatostatin (SST⁺) IWMNs was determined in the white matter of the corpus callosum in two rostrocaudally adjacent areas in the 12week old offspring of GD10 (n=10) or GD19 polyI:C dams (n=18) compared to controls (n=20). NeuN⁺ IWMN density trended to be higher in offspring from dams exposed to polyI:C at GD19, but not GD10. A subpopulation of these NeuN⁺ IWMNs was shown to express SST. PolyI:C treatment of dams induced a significant increase in the density of SST⁺ IWMNs in the offspring when delivered at both gestational stages with more regionally widespread effects observed at GD19. A positive correlation was observed between NeuN⁺ and SST⁺ IWMN density in animals exposed to polyI:C at GD19, but not controls. This is the first study to show that MIA increases IWMN density in adult offspring in a similar manner to that seen in the brain in schizophrenia. This suggests the MIA model will be useful in future studies aimed at probing the relationship between IWMNs and schizophrenia.]]> Sat 24 Mar 2018 07:35:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29335 Sat 24 Mar 2018 07:34:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27390 Sat 24 Mar 2018 07:34:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30050 Sat 24 Mar 2018 07:31:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28311 Sat 24 Mar 2018 07:27:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23306 Sat 24 Mar 2018 07:16:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23305 Sat 24 Mar 2018 07:16:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25081 Sat 24 Mar 2018 07:15:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22172 Sat 24 Mar 2018 07:14:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22690 A single nucleotide polymorphism (rs2067477) within the cholinergic muscarinic M1 receptor (CHRM1) perform less well on the Wisconsin Card Sorting Test (WCST) than those who are heterozygous. This study sought to determine whether variation in the rs2067477 genotype was associated with differential changes in brain structure. Data from 227 patients with established schizophrenia or schizoaffective disorder were obtained from the Australian Schizophrenia Research Bank. Whole-brain voxel-based morphometry was performed to compare regional grey matter volume (GMV) between the 267C/C (N=191) and 267C/A (N=36) groups. Secondary analyses tested for an effect of genotype on cognition (the WCST was not available). Individuals who were homozygous (267C/C) demonstrated significantly reduced GMV in the right precentral gyrus compared to those who were heterozygous (267C/A). These preliminary results suggest that the rs2067477 genotype is associated with brain structure in the right precentral gyrus in individuals with schizophrenia/schizoaffective disorder. Future studies are required to replicate these results and directly link the volumetric reductions with specific cognitive processes.]]> Sat 24 Mar 2018 07:11:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44131 Sat 08 Oct 2022 12:36:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42338 N = 29,125 cases and 34,836 controls), a robust polygenic signal was observed from gene sets based on TCF4, FMR1, upregulation from MIR137 and downregulation from CHD8. Additional analyses revealed a constant floor effect in the amount of variance explained, consistent with the omnigenic model. Thus, we report that putative core gene sets showed a significant effect above and beyond the floor effect that might be linked with the underlying omnigenic background. In addition, we demonstrate a method to quantify the contribution of specific gene sets within the omnigenic context.]]> Mon 22 Aug 2022 14:00:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50972 Mon 14 Aug 2023 15:19:39 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35822 Mon 09 Dec 2019 16:39:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55074 Mon 08 Apr 2024 14:10:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42814 Mon 05 Sep 2022 14:06:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49672 Fri 26 May 2023 15:35:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46603 Fri 25 Nov 2022 16:41:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51740 Fri 15 Sep 2023 18:14:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51543 Fri 08 Sep 2023 14:59:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37045 Fri 07 Aug 2020 14:34:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54564 Fri 01 Mar 2024 11:18:59 AEDT ]]>